The Effect of Folic Acid Supplementation on Endothelial Function and Arterial Stiffness Markers in Adults: A Systematic Review and Meta-Analysis

Author:

Bokayeva Kamila1ORCID,Jamka Małgorzata1ORCID,Banaszak Michalina2ORCID,Makarewicz-Bukowska Aleksandra1ORCID,Adamczak Ada1ORCID,Chrobot Maria1ORCID,Janicka Adrianna1ORCID,Jaworska Natalia1ORCID,Walkowiak Jarosław1ORCID

Affiliation:

1. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, Poland

2. Department of Bromatology, Poznan University of Medical Sciences, Rokietnicka Str. 3, 60-806 Poznań, Poland

Abstract

Folic acid might improve endothelial function, but the results are inconclusive. This systematic review evaluated the effect of folic acid supplementation on endothelial parameters and arterial stiffness in adults. The study protocol was registered with the PROSPERO database (CRD42021290195). The PubMed, Web of Sciences, Cochrane and Scopus databases were searched to identify English-language randomised controlled trials of the effect of folate supplementation on arterial stiffness and endothelial function markers in adults. There were significant differences between the effect of folic acid and placebo on flow-mediated dilation (random-effects model, standardized mean differences (SMD): 0.888, 95% confidence interval (CI): 0.447, 1.329, p < 0.001) and monocyte chemotactic protein 1 (random-effects model, SMD: −1.364, 95% CI: −2.164, −0.563, p < 0.001), but there was no significant difference in the central pulse wave velocity (fixed-effects model, SMD: −0.069, 95% CI: −0.264, 0.125, p = 0.485) and peripheral pulse wave velocity (fixed-effects model, SMD: −0.093, 95% CI: −0.263, 0.077, p = 0.284). In conclusion, folic acid might have a favourable effect on endothelial function but may not affect arterial stiffness. Further studies are needed to confirm these results.

Publisher

MDPI AG

Subject

Health Information Management,Health Informatics,Health Policy,Leadership and Management

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