Brain Activity in the Prefrontal Cortex during Cognitive Tasks and Dual Tasks in Community-Dwelling Elderly People with Pre-Frailty: A Pilot Study for Early Detection of Cognitive Decline

Abstract

We aimed to detect brain abnormalities during cognitive and motor tasks in older individuals with pre-frailty, as this could prevent dementia. Sixty elderly participants (mean age: 76.3 years; 27 healthy and 33 with pre-frailty) were included, and their motor function, cognitive function, and dual-task abilities (gait with calculation and while carrying a ball) were evaluated. Total hemoglobin (t-Hb) was measured using functional near-infrared spectroscopy (fNIRS) during tasks and resting periods. The pre-frailty group had a slightly lower gait speed than the healthy group, but there was no significant difference in cognitive function. In the pre-frailty group, the t-Hb values during the normal gait and cognitive tasks were higher than the resting value in the right prefrontal cortex, while in the healthy group, only the word frequency task (WFT) was higher. Furthermore, in the WFT, the t-Hb values were significantly lower in the pre-frailty group than in the healthy group. The results showed that pre-frail subjects had lower brain activation during the WFT in the right prefrontal cortex and excessive activity during walking, even without a noticeable cognitive decline. The differences in cerebral blood flow under the pre-frailty conditions may be a clue to detecting cognitive decline earlier.