Effects of Oral Alpha-Lipoic Acid Treatment on Diabetic Polyneuropathy: A Meta-Analysis and Systematic Review

Author:

Hsieh Ruey-Yu1,Huang I-Chen1,Chen Chiehfeng234ORCID,Sung Jia-Ying15ORCID

Affiliation:

1. Department of Neurology, Taipei Municipal Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan

2. Division of Plastic Surgery, Department of Surgery, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan

3. Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan

4. Cochrane Taiwan, Taipei Medical University, Taipei 110, Taiwan

5. Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan

Abstract

Alpha-lipoic acid (ALA) was found to improve the symptoms in patients with diabetic sensorimotor peripheral neuropathy (DSPN) by reducing oxidative stress and ameliorating microcirculation. Our meta-analysis is aimed at evaluating the effects of oral-administered ALA versus a placebo in patients with DSPN and determining the optimal dosage for this treatment. We systematically reviewed randomized controlled trials (RCTs) in the PubMed, Embase, and Cochrane databases to determine the efficacy of oral ALA for patients with DSPN. The primary outcome was total symptoms’ score (TSS), and secondary outcomes were the neurological disability score (NDS), neuropathy impaired score (NIS), NIS-lower limb (NIS-LL), vibration perception threshold (VPT), nerve conduction study (NCS) results, and global satisfaction. A subgroup analysis of the ALA dosage (600, 1200, and 1800 mg/day) was also conducted. Ten RCTs (1242 patients) were included. ALA treatment produced favorable results for TSS (a dose-related trend was observed), NDS, and the global satisfaction score. For VAS, VPT, NIS-LL, and NCS results, ALA did not produce favorable results. ALA treatment had favorable effects on DSPN by reducing sensory symptoms, and it resulted in a dose-dependent response relative to the placebo for TSS and the global satisfaction score. The use of ALA to prevent neurological symptoms should be further researched.

Funder

Taipei Municipal Wan Fang Hospital

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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