Telomere Length: A Cardiovascular Biomarker and a Novel Therapeutic Target
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Published:2022-12-16
Issue:24
Volume:23
Page:16010
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Sagris MariosORCID, Theofilis PanagiotisORCID, Antonopoulos Alexios S., Tsioufis Konstantinos, Tousoulis Dimitris
Abstract
Coronary artery disease (CAD) is a multifactorial disease with a high prevalence, particularly in developing countries. Currently, the investigation of telomeres as a potential tool for the early detection of the atherosclerotic disease seems to be a promising method. Telomeres are repetitive DNA sequences located at the extremities of chromosomes that maintain genetic stability. Telomere length (TL) has been associated with several human disorders and diseases while its attrition rate varies significantly in the population. The rate of TL shortening ranges between 20 and 50 bp and is affected by factors such as the end-replication phenomenon, oxidative stress, and other DNA-damaging agents. In this review, we delve not only into the pathophysiology of TL shortening but also into its association with cardiovascular disease and the progression of atherosclerosis. We also provide current and future treatment options based on TL and telomerase function, trying to highlight the importance of these cutting-edge developments and their clinical relevance.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference120 articles.
1. Sagris, M., Theofilis, P., Antonopoulos, A.S., Tsioufis, C., Oikonomou, E., Antoniades, C., Crea, F., Kaski, J.C., and Tousoulis, D. (2021). Inflammatory Mechanisms in COVID-19 and Atherosclerosis: Current Pharmaceutical Perspectives. Int. J. Mol. Sci., 22. 2. Sagris, M., Theofilis, P., Antonopoulos, A.S., Oikonomou, E., Paschaliori, C., Galiatsatos, N., Tsioufis, K., and Tousoulis, D. (2021). Inflammation in Coronary Microvascular Dysfunction. Int. J. Mol. Sci., 22. 3. Theofilis, P., Sagris, M., Antonopoulos, A.S., Oikonomou, E., Tsioufis, C., and Tousoulis, D. (2021). Inflammatory Mediators of Platelet Activation: Focus on Atherosclerosis and COVID-19. Int. J. Mol. Sci., 22. 4. Theofilis, P., Sagris, M., Oikonomou, E., Antonopoulos, A.S., Lazaros, G., Theofilis, A., Papastamos, C., Papaioannou, S., Siasos, G., and Tsioufis, K. (2022). Extracellular matrix remodeling biomarkers in coronary artery disease. Curr. Top. Med. Chem., 2355–2367. 5. Oikonomou, E., Tsaplaris, P., Anastasiou, A., Xenou, M., Lampsas, S., Siasos, G., Pantelidis, P., Theofilis, P., Tsatsaragkou, A., and Katsarou, O. (2022). Interleukin-1 in Coronary Artery Disease. Curr. Top. Med. Chem., 2368–2389.
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