Author:
Spencer Peter S.,Chen Xiao
Abstract
The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and with the largely sub-clinical nerve damage associated with old age. These conditions may be linked by metabolites that adduct and cross-link neuroproteins required for the maintenance of axonal transport and nerve fiber integrity in the peripheral and central nervous system.
Funder
Nature Science Foundation of China
Subject
Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology
Cited by
8 articles.
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