Abstract
Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.
Funder
The Ministry of Science and Technology of taiwan
China Medical University
Reference66 articles.
1. Screening for prostate cancer: Us preventive services task force recommendation statement;Force;Jama,2018
2. Prostate cancer incidence and survival, by stage and race/ethnicity-united states, 2001–2017;Siegel;Mmwr. Morb. Mortal. Wkly. Rep.,2020
3. Global trends and prostate cancer: A review of incidence, detection, and mortality as influenced by race, ethnicity, and geographic location;Taitt;Am. J. Mens. Health,2018
4. Matrix metalloproteinases (mmps) and tissue inhibitors of metalloproteinases (timps): Positive and negative regulators in tumor cell adhesion;Bourboulia;Semin. Cancer Biol.,2010
5. Matrix metalloproteinases: Regulators of the tumor microenvironment;Kessenbrock;Cell,2010
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