NAMPT enhances LOX expression and promotes metastasis in human chondrosarcoma cells by inhibiting miR‐26b‐5p synthesis-Reference-Cited by-同舟云学术

NAMPT enhances LOX expression and promotes metastasis in human chondrosarcoma cells by inhibiting miR‐26b‐5p synthesis

Published:2024-06-28 Issue:9 Volume:239 Page:
ISSN:0021-9541
Container-title:Journal of Cellular Physiology
language:en
Short-container-title:Journal Cellular Physiology

Author:

Lin Chih‐Yang¹,Law Yat‐Yin²³,Yu Cheng‐Chieh⁴,Wu Yu‐Ying³⁵⁶,Hou Sheng‐Mou⁷⁸,Chen Wei‐Li¹,Yang Shang‐Yu⁹,Tsai Chun‐Hao¹⁰¹¹,Lo Yuan‐Shun¹¹¹²¹³,Fong Yi‐Chin¹⁰¹¹¹²,Tang Chih‐Hsin⁴¹⁴¹⁵¹⁶¹⁷^ORCID

Affiliation:

1. Translational Medicine Center Shin Kong Wu Ho‐Su Memorial Hospital Taipei Taiwan

2. School of Medicine Chung Shan Medical University Taichung Taiwan

3. Department of Orthopedics Chung Shan Medical University Hospital Taichung Taiwan

4. Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan

5. Institute of Medicine Chung Shan Medical University Taichung Taiwan

6. Department of Orthopedics Penghu Hospital, Ministry of Health and Welfare Penghu Taiwan

7. The Director's Office Shin Kong Wu Ho‐Su Memorial Hospital Taipei Taiwan

8. Department of Research Taiwan Blood Services Foundation Taipei Taiwan

9. Department of Healthcare Administration, College of Medical and Health Science Asia University Taichung Taiwan

10. Department of Sports Medicine, College of Health Care China Medical University Taichung Taiwan

11. Department of Orthopedic Surgery China Medical University Hospital Taichung Taiwan

12. Department of Orthopedic Surgery China Medical University Beigang Hospital Yunlin Taiwan

13. Graduate Institute of Precision Engineering National Chung Hsing University Taichung Taiwan

14. Department of Pharmacology, School of Medicine China Medical University Taichung Taiwan

15. Chinese Medicine Research Center China Medical University Taichung Taiwan

16. Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science Asia University Taichung Taiwan

17. Department of Medical Research China Medical University Hsinchu Hospital Hsinchu Taiwan

Abstract

AbstractChondrosarcoma is a malignant bone tumor that emerges from abnormalities in cartilaginous tissue and is related with lung metastases. Nicotinamide phosphoribosyltransferase (NAMPT) is an adipocytokine reported to enhance tumor metastasis. Our results from clinical samples and the Gene Expression Omnibus data set reveal that NAMPT levels are markedly higher in chondrosarcoma patients than in normal individuals. NAMPT stimulation significantly increased lysyl oxidase (LOX) production in chondrosarcoma cells. Additionally, NAMPT increased LOX‐dependent cell migration and invasion in chondrosarcoma by suppressing miR‐26b‐5p generation through the c‐Src and Akt signaling pathways. Overexpression of NAMPT promoted chondrosarcoma metastasis to the lung in vivo. Furthermore, knockdown of LOX counteracted NAMPT‐facilitated metastasis. Thus, the NAMPT/LOX axis presents a novel target for treating the metastasis of chondrosarcoma.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcp.31345

Reference58 articles.

1. Antcin K inhibits VEGF‐dependent angiogenesis in human rheumatoid arthritis synovial fibroblasts

2. Diagnostic and Therapeutic Implications of microRNAs in Non-Small Cell Lung Cancer

3. Obesity and cancer risk: Emerging biological mechanisms and perspectives

4. miR30a Inhibits LOX Expression and Anaplastic Thyroid Cancer Progression

5. Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NFκB Signaling and Inflammatory Lung Injury