Author:
Yu Kun,Yu Chengxin,Jiao Liping,Miao Kun,Ni Li,Rao Xiaoquan,Zhou Ling,Zhao Chunxia
Abstract
Myeloid-derived suppressor cells (MDSCs) are a group of immature and heterogeneous myeloid cells with immunosuppressive functions. MDSCs play important roles in the pathogenesis of cancer, chronic inflammatory diseases, and many autoimmune disorders. The accumulation and activation of MDSCs can be regulated by tumor necrosis factor α (TNF-α). In this review, we summarize the roles played by TNF-α in the recruitment, immunosuppressive functions, and chemotaxis of MDSCs, and discuss the potential therapeutic effects of TNF-α upon these cells in tumor growth and some inflammatory disorders.
Funder
National Natural Science Foundation of China
Program for Huazhong University of Science and Technology Academic Frontier Youth Team
Subject
Molecular Biology,Biochemistry
Cited by
1 articles.
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