Diet Change Improves Obesity and Lipid Deposition in High-Fat Diet-Induced Mice
-
Published:2023-11-30
Issue:23
Volume:15
Page:4978
-
ISSN:2072-6643
-
Container-title:Nutrients
-
language:en
-
Short-container-title:Nutrients
Author:
Ji Tengteng1, Fang Bing1ORCID, Wu Fang1, Liu Yaqiong1, Cheng Le1, Li Yixuan1, Wang Ran1, Zhu Longjiao1
Affiliation:
1. Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China
Abstract
The number of obese people is increasing dramatically worldwide, and one of the major causes of obesity is excess energy due to high-fat diets. Several studies have shown that reducing food and energy intake represents a key intervention or treatment to combat overweight/obesity. Here, we conducted a 12-week energy-restricted dietary intervention for high-fat diet-induced obese mice (C57BL/6J) to investigate the effectiveness of diet change in improving obesity. The results revealed that the diet change from HFD to NFD significantly reduced weight gain and subcutaneous adipose tissue weight in high-fat diet-induced obese mice, providing scientific evidence for the effectiveness of diet change in improving body weight and fat deposition in obese individuals. Regarding the potential explanations for these observations, weight reduction may be attributed to the excessive enlargement of adipocytes in the white adipose tissue of obese mice that were inhibited. Diet change significantly promoted lipolysis in the adipose tissue (eWAT: Adrb3, Plin1, HSL, and CPTA1a; ingWAT: CPT1a) and liver (reduced content of nonesterified fatty acids), and reduced lipogenesis in ingWAT (Dgat2). Moreover, the proportion of proliferative stem cells in vWAT and sWAT changed dramatically with diet change. Overall, our study reveals the phenotypic, structural, and metabolic diversity of multiple tissues (vWAT and sWAT) in response to diet change and identifies a role for adipocyte stem cells in the tissue specificity of diet change.
Funder
National Key Research and Development Program of China Beijing Nova Program
Subject
Food Science,Nutrition and Dietetics
Reference58 articles.
1. Calorie restriction and cardiometabolic health;Fontana;Eur. J. Cardiovasc. Prev. Rehabil.,2008 2. Bastías-Pérez, M., Serra, D., and Herrero, L. (2020). Dietary options for rodents in the study of obesity. Nutrients, 12. 3. Cioffi, F., Giacco, A., Petito, G., De Matteis, R., Senese, R., Lombardi, A., De Lange, P., Moreno, M., Goglia, F., and Lanni, A. (2022). Altered mitochondrial quality control in rats with metabolic dysfunction-associated fatty liver disease (MAFLD) induced by high-fat feeding. Genes, 13. 4. Liao, J.T., Huang, Y.W., Hou, C.Y., Wang, J.J., Wu, C.C., and Hsieh, S.L. (2023). D-Limonene promotes anti-obesity in 3T3-L1 adipocytes and high-calorie diet-induced obese rats by activating the ampk signaling pathway. Nutrients, 15. 5. Yan, J., Bak, J., Go, Y., Park, J., Park, M., Lee, H.J., and Kim, H. (2023). Scytosiphon lomentaria extract ameliorates obesity and modulates gut microbiota in high-fat-diet-fed mice. Nutrients, 15.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|