Abstract
Patients treated for traumatic brain injury (TBI) are in metabolic crises because of the trauma and underfeeding. We utilized fractional gluconeogenesis (fGNG) to assess nutritional adequacy in ad libitum-fed and calorically-restricted rats following TBI. Male Sprague–Dawley individually housed rats 49 days of age were randomly assigned into four groups: ad libitum (AL) fed control (AL-Con, sham), AL plus TBI (AL+TBI), caloric restriction (CR) control (CR-Con, sham), and CR plus TBI (CR+TBI). From days 1–7 animals were given AL access to food and water containing 6% deuterium oxide (D2O). On day 8, a pre-intervention blood sample was drawn from each animal, and TBI, sham injury, and CR protocols were initiated. On day 22, the animals were euthanized, and blood was collected to measure fGNG. Pre-intervention, there was no significant difference in fGNG among groups (p ≥ 0.05). There was a significant increase in fGNG due to caloric restriction, independent of TBI (p ≤ 0.05). In addition, fGNG may provide a real-time, personalized biomarker for assessing patient dietary caloric needs.
Funder
PAC 12 Athletic Association
UC, Berkeley Center for Research and Education on Aging
Subject
Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism
Reference41 articles.
1. Peterson, A.B., Thomas, K.E., and Zhou, H. (2022). Surveillance Report of Traumatic Brain Injury-related Deaths by Age Group, Sex, and Mechanism of Injury—United States, 2018 and 2019.
2. Functionally-detected cognitive impairment in high school football players without clinically-diagnosed concussion;J. Neurotrauma,2014
3. Indirect calorimetry as point of care testing;Clin. Nutr.,2019
4. Resting energy expenditure in non-ventilated, non-sedated patients recovering from serious traumatic brain injury: Comparison of prediction equations with indirect calorimetry values;Clin. Nutr.,2009
5. The metabolic response to acute traumatic brain injury and implications for nutritional support;J. Head Trauma Rehabil.,1999
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