Novel Investigational Agents and Pathways That May Influence the Future Management of Acute Myeloid Leukemia-Reference-Cited by-同舟云学术

Novel Investigational Agents and Pathways That May Influence the Future Management of Acute Myeloid Leukemia

Published:2023-05-29 Issue:11 Volume:15 Page:2958
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Premnath Naveen¹^ORCID,Madanat Yazan F.¹²^ORCID

Affiliation:

1. Division of Hematology and Medical Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA

2. Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75235, USA

Abstract

Acute Myeloid leukemia (AML) is a clinically heterogeneous disease with a 5-year overall survival of 32% between 2012 to 2018. The above number severely dwindles with age and adverse risk of disease, presenting opportunities for new drug development and is an area of dire unmet need. Basic science and clinical investigators across the world have been working on many new and old molecule formulations and combination strategies to improve outcomes in this disease. In this review, we discuss select promising novel agents in various stages of clinical development for patients with AML.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/11/2958/pdf

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