Editorial: The Application of Proteogenomics to Urine Analysis for the Identification of Novel Biomarkers of Prostate Cancer: An Exploratory Study-Reference-Cited by-同舟云学术

Editorial: The Application of Proteogenomics to Urine Analysis for the Identification of Novel Biomarkers of Prostate Cancer: An Exploratory Study

Published:2023-08-17 Issue:16 Volume:15 Page:4143
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Gamallat Yaser¹²^ORCID,Bismar Tarek A.¹²³⁴^ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada

2. Department of Oncology, Biochemistry and Molecular Biology, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada

3. Departments of Pathology & Laboratory Medicine, Alberta Precision Laboratories, Rockyview General Hospital, Calgary, AB T2V 1P9, Canada

4. Prostate Cancer Center, Rockyview General Hospital, Calgary, AB T2V 1P9, Canada

Abstract

In this editorial context, we aim to leverage the potential of proteogenomics, which integrates genomic and proteomic data, to discover novel biomarkers that can aid in the diagnosis and management of prostate cancer. We highlight the importance of proteogenomics for understanding the functional consequences of somatic mutations in cancer and demonstrating how proteogenomic analysis can provide insights into the effects of genetic alterations on the proteomic landscape and identify potential therapeutic targets. This article also emphasizes the potential of urine analysis for the detection of prostate cancer. Overall, our editorial paper provides general insights on the application of proteogenomics to urine analysis for the identification of novel biomarkers of prostate cancer.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/16/4143/pdf

Reference14 articles.

1. Cancer statistics, 2023;Siegel;CA Cancer J. Clin.,2023

2. Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies;Brokane;Front. Mol. Biosci.,2023

3. Lima, T., Barros, A.S., Trindade, F., Ferreira, R., Leite-Moreira, A., Barros-Silva, D., Jeronimo, C., Araujo, L., Henrique, R., and Vitorino, R. (2022). Application of Proteogenomics to Urine Analysis towards the Identification of Novel Biomarkers of Prostate Cancer: An Exploratory Study. Cancers, 14.

4. Frantzi, M., Culig, Z., Heidegger, I., Mokou, M., Latosinska, A., Roesch, M.C., Merseburger, A.S., Makridakis, M., Vlahou, A., and Blanca-Pedregosa, A. (2023). Mass Spectrometry-Based Biomarkers to Detect Prostate Cancer: A Multicentric Study Based on Non-Invasive Urine Collection without Prior Digital Rectal Examination. Cancers, 15.

5. Current Challenges and Implications of Proteogenomic Approaches in Prostate Cancer;Shukla;Curr. Top. Med. Chem.,2020