Extra-Virgin Olive Oil and Its Minor Compounds Influence Apoptosis in Experimental Mammary Tumors and Human Breast Cancer Cell Lines

Author:

Garcia-Guasch Maite,Medrano Mireia,Costa Irmgard,Vela Elena,Grau Marta,Escrich Eduard,Moral RaquelORCID

Abstract

Breast cancer is the most common malignancy among women worldwide. Modifiable factors such as nutrition have a role in its etiology. In experimental tumors, we have observed the differential influence of high-fat diets in metabolic pathways, suggesting a different balance in proliferation/apoptosis. In this work, we analyzed the effects of a diet high in n-6 polyunsaturated fatty acids (PUFA) and a diet high in extra-virgin olive oil (EVOO) on the histopathological features and different cell death pathways in the dimethylbenz(a)anthracene-induced breast cancer model. The diet high in n-6 PUFA had a stimulating effect on the morphological aggressiveness of tumors and their proliferation, while no significant differences were found in groups fed the EVOO-enriched diet in comparison to a low-fat control group. The high-EVOO diet induced modifications in proteins involved in several cell death pathways. In vitro analysis in different human breast cancer cell lines showed an effect of EVOO minor compounds (especially hydroxytyrosol), but not of fatty acids, decreasing viability while increasing apoptosis. The results suggest an effect of dietary lipids on tumor molecular contexts that result in the modulation of different pathways, highlighting the importance of apoptosis in the interplay of survival processes and how dietary habits may have an impact on breast cancer risk.

Funder

Minsterio de Educación y Ciencia

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Reference52 articles.

1. IARC Global Cancer Observatory. GLOBOCANhttps://gco.iarc.fr

2. Diet, Nutrition, Physical Activity and Cancer: A Global Perspective. Continuous Update Project Expert Reporthttps://www.wcrf.org/diet-and-cancer/

3. Olive oil, and other dietary lipids, in cancer: Experimental approaches;Escrich,2006

4. Modulatory Effects and Molecular Mechanisms of Olive Oil and Other Dietary Lipids in Breast Cancer

5. Adherence to the mediterranean diet and risk of breast cancer in the European prospective investigation into cancer and nutrition cohort study

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