Affiliation:
1. Analysis of Circulating Tumour Cells Lab, Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece
2. St. Barthlomew’s Hospital, Barts Health NHS Trust, London EC1A 7BE, UK
Abstract
Over the last decade, liquid biopsy has gained much attention as a powerful tool in personalized medicine since it enables monitoring cancer evolution and follow-up of cancer patients in real time. Through minimally invasive procedures, liquid biopsy provides important information through the analysis of circulating tumour cells (CTCs) and circulating tumour-derived material, such as circulating tumour DNA (ctDNA), circulating miRNAs (cfmiRNAs) and extracellular vehicles (EVs). CTC analysis has already had an important impact on the prognosis, detection of minimal residual disease (MRD), treatment selection and monitoring of cancer patients. Numerous clinical trials nowadays include a liquid biopsy arm. CTC analysis is now an exponentially expanding field in almost all types of solid cancers. Functional studies, mainly based on CTC-derived cell-lines and CTC-derived explants (CDx), provide important insights into the metastatic process. The purpose of this review is to summarize the latest findings on the clinical significance of CTCs for the management of cancer patients, covering the last four years. This review focuses on providing a comprehensive overview of CTC analysis in breast, prostate and non-small-cell lung cancer. The unique potential of CTC single-cell analysis for understanding metastasis biology, and the importance of quality control and standardization of methodologies used in this field, is also discussed.
Funder
European Union and Greek national funds through the Operational Program: Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH—CREATE—INNOVATE
Reference103 articles.
1. Rifai, N., Horvath, A.-R., and Wittwer, C. (2017). Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Elsevier Ltd.. [6th ed.].
2. Liquid Biopsy: From Discovery to Clinical Application;Pantel;Cancer Discov.,2021
3. Rushton, A.J., Nteliopoulos, G., Shaw, J.A., and Coombes, R.C. (2021). A Review of Circulating Tumour Cell Enrichment Technologies. Cancers, 13.
4. Defining the dimensions of circulating tumor cells in a large series of breast, prostate, colon, and bladder cancer patients;Mendelaar;Mol. Oncol.,2021
5. Vidlarova, M., Rehulkova, A., Stejskal, P., Prokopova, A., Slavik, H., Hajduch, M., and Srovnal, J. (2023). Recent Advances in Methods for Circulating Tumor Cell Detection. Int. J. Mol. Sci., 24.
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献