Trends in Cancer Incidence in Different Antiretroviral Treatment-Eras amongst People with HIV-Reference-Cited by-同舟云学术

Trends in Cancer Incidence in Different Antiretroviral Treatment-Eras amongst People with HIV

Published:2023-07-15 Issue:14 Volume:15 Page:3640
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Greenberg Lauren¹,Ryom Lene¹²,Bakowska Elzbieta³,Wit Ferdinand⁴,Bucher Heiner C.⁵,Braun Dominique L.⁵^ORCID,Phillips Andrew⁶,Sabin Caroline⁶,d’Arminio Monforte Antonella⁷^ORCID,Zangerle Robert⁸^ORCID,Smith Colette⁹,De Wit Stéphane¹⁰,Bonnet Fabrice¹¹,Pradier Christian¹²,Mussini Cristina¹³,Muccini Camilla¹⁴^ORCID,Vehreschild Jörg J.¹⁵,Hoy Jennifer¹⁶¹⁷^ORCID,Svedhem Veronica¹⁸,Miró Jose M.¹⁹²⁰^ORCID,Wasmuth Jan-Christian²¹,Reiss Peter²²^ORCID,Llibre Josep M.²³^ORCID,Chkhartishvili Nikoloz²⁴,Stephan Christoph²⁵^ORCID,Hatleberg Camilla I.¹,Neesgaard Bastian¹,Peters Lars¹,Jaschinski Nadine¹,Dedes Nikos²⁶,Kuzovatova Elena²⁷,Van Der Valk Marc⁴²⁸,Menozzi Marianna¹³,Lehmann Clara¹⁵,Petoumenos Kathy¹⁶¹⁷,Garges Harmony²⁹,Rooney Jim³⁰,Young Lital³¹,Lundgren Jens D.¹,Bansi-Matharu Loveleen⁶,Mocroft Amanda¹⁶,

Affiliation:

1. CHIP, Centre of Excellence for Health, Immunity and Infections Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark

2. Department of Infectious Diseases 144, Hvidovre University Hospital, DK-2650 Copenhagen, Denmark

3. Wojewódzki Szpital Zakaźny, 01-201 Warsaw, Poland

4. Stichting HIV Monitoring, 1105 BD Amsterdam, The Netherlands

5. Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, 8001 Zurich, Switzerland

6. Centre for Clinical Research, Epidemiology, Modelling and Evaluation, Institute for Global Health, University College London, London NW3 2PF, UK

7. Italian Cohort Naive Antiretrovirals (ICONA), ASST Santi Paolo e Carlo, 20142 Milano, Italy

8. Austrian HIV Cohort Study (AHIVCOS), Medizinische Universität Innsbruck, 6020 Innsbruch, Austria

9. The Royal Free HIV Cohort Study, Royal Free Hospital, University College London, London NW3 2PF, UK

10. CHU Saint-Pierre, Centre de Recherche en Maladies Infectieuses a.s.b.l., 1000 Brussels, Belgium

11. CHU de Bordeaux and Bordeaux University, BPH, INSERM U1219, 33076 Bordeaux, France

12. Nice HIV Cohort, Université Côte d’Azur et Centre Hospitalier Universitaire, 06000 Nice, France

13. Modena HIV Cohort, Università Degli Studi Di Modena and Reggio Emilia, 41125 Modena, Italy

14. San Raffaele Scientific Institute, Università Vita-Salute San Raffaele, 20132 Milano, Italy

15. University Hospital Cologne, 50937 Cologne, Germany

16. Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne 3004, Australia

17. The Australian HIV Observational Database (AHOD), Kirby Institute, UNSW, Sydney 2052, Australia

18. Swedish InfCareHIV Cohort, Karolinska University Hospital, 141 86 Stockholm, Sweden

19. Infectious Diseases Service, Hospital Clinic-IDIBAPS, University of Barcelona, 08036 Barcelona, Spain

20. CIBERINFEC, Instituto de Salud Carlos III, 28029 Madrid, Spain

21. University Hospital Bonn, 53127 Bonn, Germany

22. Amsterdam UMC Location, Department of Global Health, University of Amsterdam, Global Health, Meibergdreef 9, 1105 Amsterdam, The Netherlands

23. Department of Infectious Diseases, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain

24. Georgian National AIDS Health Information System (AIDS HIS), Infectious Diseases, AIDS and Clinical Immunology Research Center, Tbilisi, Georgia

25. HIV Center, University Hospital Frankfurt, Goethe-University, 60596 Frankfurt, Germany

26. European AIDS Treatment Group, 1000 Brussels, Belgium

27. Nizhny Novgorod Scientific and Research Institute, 603155 Nizhny Novgorod, Russia

28. Amsterdam University Medical Centers, University of Amsterdam, 1117 Amsterdam, The Netherlands

29. ViiV Healthcare, Research Triangle Park, Durham, NC 27709, USA

30. Gilead Science, Foster City, CA 94404, USA

31. Merck Sharp & Dohme, Rahway, NJ 07065, USA

Abstract

Despite cancer being a leading comorbidity amongst individuals with HIV, there are limited data assessing cancer trends across different antiretroviral therapy (ART)-eras. We calculated age-standardised cancer incidence rates (IRs) from 2006–2021 in two international cohort collaborations (D:A:D and RESPOND). Poisson regression was used to assess temporal trends, adjusted for potential confounders. Amongst 64,937 individuals (31% ART-naïve at baseline) and 490,376 total person-years of follow-up (PYFU), there were 3763 incident cancers (IR 7.7/1000 PYFU [95% CI 7.4, 7.9]): 950 AIDS-defining cancers (ADCs), 2813 non-ADCs, 1677 infection-related cancers, 1372 smoking-related cancers, and 719 BMI-related cancers (groups were not mutually exclusive). Age-standardised IRs for overall cancer remained fairly constant over time (8.22/1000 PYFU [7.52, 8.97] in 2006–2007, 7.54 [6.59, 8.59] in 2020–2021). The incidence of ADCs (3.23 [2.79, 3.72], 0.99 [0.67, 1.42]) and infection-related cancers (4.83 [4.2, 5.41], 2.43 [1.90, 3.05]) decreased over time, whilst the incidence of non-ADCs (4.99 [4.44, 5.58], 6.55 [5.67, 7.53]), smoking-related cancers (2.38 [2.01, 2.79], 3.25 [2.63–3.96]), and BMI-related cancers (1.07 [0.83, 1.37], 1.88 [1.42, 2.44]) increased. Trends were similar after adjusting for demographics, comorbidities, HIV-related factors, and ART use. These results highlight the need for better prevention strategies to reduce the incidence of NADCs, smoking-, and BMI-related cancers.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/14/3640/pdf

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