Cancer in people with multidrug-resistant HIV-Reference-Cited by-同舟云学术

Cancer in people with multidrug-resistant HIV

Published:2024-08-29 Issue:12 Volume:38 Page:1801-1806
ISSN:0269-9370
Container-title:AIDS
language:en
Short-container-title:

Author:

Clemente Tommaso¹²,Pontillo Domenico²,Malagnino Vincenzo³,Calza Leonardo⁴,Di Biagio Antonio⁵⁶,Cenderello Giovanni⁷,Lolatto Riccardo²,Manzillo Elio⁸,Moioli Maria Cristina⁹,De Socio Giuseppe Vittorio¹⁰,Castagna Antonella¹²,Spagnuolo Vincenzo²,

Affiliation:

1. Vita-Salute San Raffaele University

2. Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan

3. Department of Medicine of Systems, University of Rome Tor Vergata, Rome

4. Infectious Diseases Unit, IRCCS Policlinico di Sant’Orsola, University of Bologna, Bologna

5. IRCCS Ospedale Policlinico San Martino

6. Department of Health's Sciences, University of Genoa, Genoa

7. Infectious Diseases Department, Sanremo Hospital, Sanremo

8. Ospedale dei Colli, Naples

9. Department of Infectious Diseases, ASST Grande Ospedale Metropolitano Niguarda, Milan

10. Unit of Infectious Diseases, Santa Maria Hospital, Perugia, Italy.

Abstract

Retrospective, cohort analysis including people with HIV and 4-class drug resistance (4DR). The 8-year probability of malignancy after first evidence of 4DR was 12%, with an incidence of 1.6/100 person years of follow-up. Cancer risk tended to increase with higher precancer viremia copy-years adjusted for time [per 1 − log10 copies/ml higher: adjusted hazard ratio (aHR) = 1.35; 95% confidence interval (95% CI) = 0.98–1.85] and male sex-assigned-at-birth (aHR = 2.50; 95% CI = 0.86–7.27). Efforts to achieve long-term undetectability, risk factor control, prevention, and more aggressive cancer screening are needed in this fragile population.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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