An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: An ATP-Competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent-Reference-Cited by-同舟云学术

An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: An ATP-Competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent

Published:2014-09-19 Issue:9 Volume:12 Page:4833-4850
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Li Linfeng,Abraham Adedoyin,Zhou Qiong,Ali Hadi,O'Brien Jeremy,Hamill Brayden,Arcaroli John,Messersmith Wells,LaBarbera Daniel

Funder

U.S. Department of Defense

Publisher

MDPI AG

Subject

Drug Discovery,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science

Link

http://www.mdpi.com/1660-3397/12/9/4833/pdf

Reference62 articles.

1. Catalytic function of DNA topoisomerase II;Osheroff;BioEssays: News Rev. Mol. Cell. Dev. Biol.,1991

2. Structure and mechanism of DNA topoisomerase II

3. DNA Topoisomerases: Structure, Function, and Mechanism

4. All tangled up: how cells direct, manage and exploit topoisomerase function

5. The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks

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