Marine Natural Products with High Anticancer Activities

Author:

Matulja Dario1,Wittine Karlo1,Malatesti Nela1,Laclef Sylvain2,Turks Maris3,Markovic Maria Kolympadi4,Ambrožić Gabriela4,Marković Dean1

Affiliation:

1. Department of Biotechnology, University of Rijeka, Radmile Matejcic 2, 51000 Rijeka, Croatia

2. Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources (LG2A), CNRS FRE 3517, 33 rue Saint-Leu, 80039 Amiens, France

3. Faculty of Material Science and Applied Chemistry, Riga Technical University, P. Valdena Str. 3, Riga, LV-1007, Latvia

4. Department of Physics, and Center for Micro- and Nanosciences and Technologies, University of Rijeka, Radmile Matejcic 2, 51000 Rijeka, Croatia

Abstract

This review covers recent literature from 2012-2019 concerning 170 marine natural products and their semisynthetic analogues with strong anticancer biological activities. Reports that shed light on cellular and molecular mechanisms and biological functions of these compounds, thus advancing the understanding in cancer biology are also included. Biosynthetic studies and total syntheses, which have provided access to derivatives and have contributed to the proper structure or stereochemistry elucidation or revision are mentioned. The natural compounds isolated from marine organisms are divided into nine groups, namely: alkaloids, sterols and steroids, glycosides, terpenes and terpenoids, macrolides, polypeptides, quinones, phenols and polyphenols, and miscellaneous products. An emphasis is placed on several drugs originating from marine natural products that have already been marketed or are currently in clinical trials.

Funder

European Regional Development Fund

Croatian Science Foundation

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

Cited by 31 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Human Topoisomerases and Caspases: Important Targets in Cancer Therapy;Alternative Remedies and Natural Products for Cancer Therapy: An Integrative Approach;2023-10-31

2. Aggregation‐enabled alkene insertion into carbon–halogen bonds;Aggregate;2023-04-28

3. Analogues of Anticancer Natural Products: Chiral Aspects;International Journal of Molecular Sciences;2023-03-16

4. Naturally Occurring Organohalogen Compounds—A Comprehensive Review;Progress in the Chemistry of Organic Natural Products;2023

5. Anti-Mitoticpotential Identification of Nyale (Eunice sp.) in The Tourism Area of Kuta Beach, Lombok Island, West Nusa Tenggara;Open Access Macedonian Journal of Medical Sciences;2022-08-18

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3