Marine Natural Products with High Anticancer Activities-Reference-Cited by-同舟云学术

Marine Natural Products with High Anticancer Activities

Published:2020-03-26 Issue:8 Volume:27 Page:1243-1307
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Matulja Dario¹,Wittine Karlo¹,Malatesti Nela¹,Laclef Sylvain²,Turks Maris³,Markovic Maria Kolympadi⁴,Ambrožić Gabriela⁴,Marković Dean¹

Affiliation:

1. Department of Biotechnology, University of Rijeka, Radmile Matejcic 2, 51000 Rijeka, Croatia

2. Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources (LG2A), CNRS FRE 3517, 33 rue Saint-Leu, 80039 Amiens, France

3. Faculty of Material Science and Applied Chemistry, Riga Technical University, P. Valdena Str. 3, Riga, LV-1007, Latvia

4. Department of Physics, and Center for Micro- and Nanosciences and Technologies, University of Rijeka, Radmile Matejcic 2, 51000 Rijeka, Croatia

Abstract

This review covers recent literature from 2012-2019 concerning 170 marine natural products and their semisynthetic analogues with strong anticancer biological activities. Reports that shed light on cellular and molecular mechanisms and biological functions of these compounds, thus advancing the understanding in cancer biology are also included. Biosynthetic studies and total syntheses, which have provided access to derivatives and have contributed to the proper structure or stereochemistry elucidation or revision are mentioned. The natural compounds isolated from marine organisms are divided into nine groups, namely: alkaloids, sterols and steroids, glycosides, terpenes and terpenoids, macrolides, polypeptides, quinones, phenols and polyphenols, and miscellaneous products. An emphasis is placed on several drugs originating from marine natural products that have already been marketed or are currently in clinical trials.

Funder

European Regional Development Fund

Croatian Science Foundation

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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