CeO2-Azacrown Conjugate as a Nanoplatform for Combined Radiopharmaceuticals

Author:

Khabirova SofiaORCID,Aleshin GlebORCID,Plakhova Tatiana,Zubenko Anastasia,Shchukina AnnaORCID,Fedorova Olga,Averin Aleksey,Belova Ekaterina,Bazarkina Elena,Kvashnina Kristina,Kalmykov Stepan

Abstract

This study is one of the first attempts to assess CeO2 nanoparticles as a nanoplatform for radiopharmaceuticals with radionuclides. The process of functionalization using a bifunctional azacrown ligand is described, and the resulting conjugates are characterized by IR and Raman spectroscopy. Their complexes with 207Bi show a high stability in medically relevant media, thus encouraging the further study of these conjugates in vivo as potential combined radiopharmaceuticals.

Funder

Russian Science Foundation

Russian Ministry of Science and Education

European Research Council

Publisher

MDPI AG

Subject

General Materials Science,General Chemical Engineering

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