Author:
Ošťádalová I,Charvátová Z,Wilhelm J
Abstract
The aim of the study was to characterize a) the lipofuscin-like
pigment (LFP) accumulation (an indicator of ROS production) in
the rat heart during early postnatal period and b) possible
antioxidative role of selenium. Experimental animals received
Na2SeO3 in drinking water during gravidity and up to day 15 post
partum. Two fluorophores of LFP in the hearts of 1-, 4-, 7- and
15-day-old rats were evaluated by fluorescent analysis. The
highest level of heart/body weight ratio in control rats was
observed on day 4, in the Se-supplemented rats on day 7.
Cardiac LFP content in controls increased from postnatal day 4, in
the hearts of Se-supplemented rats the LFP content increased
already from day 1. As compared with the Se-supplemented
group the LFP content of control hearts was significantly higher
on day 1 but significantly lower on day 4. LFP concentration in
control hearts decreased from postnatal day 1 to 4; this decrease
was followed by significant increase until day 7 and decrease to
day 15. LFP concentration in the Se-supplemented hearts was
the highest on postnatal day 7; it differed from controls on day 1
and 4. Significant changes of LFP suggest an important role of
ROS during critical ontogenetic period.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
16 articles.
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