Affiliation:
1. Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
Abstract
Continuous monitoring of the intracranial pressure (ICP) detects impending intracranial hypertension resulting from the impaired intracranial volume homeostasis, when expanding volume generates pressure increase. In this study, cellular brain edema (CE) was induced in rats by water intoxication (WI). Methylprednisolone (MP) was administered intraperitoneally (i.p.) before the start of CE induction, during the induction and after the induction. ICP was monitored for 60 min within 20 h after the completion of the CE induction by fibreoptic pressure transmitter. In rats with induced CE, ICP was increased (MeanSEM: 14.25±2.12) as well as in rats with MP administration before the start of CE induction (10.55±1.27). In control rats without CE induction (4.62±0.24) as well as in rats with MP applied during CE induction (5.52±1.32) and in rats with MP applied after the end of CE induction (6.23±0.73) ICP was normal. In the last two groups of rats, though the CE was induced, intracranial volume homeostasis was not impaired, intracranial volume as well as ICP were not increased. It is possible to conclude that methylprednisolone significantly influenced intracranial homeostasis and thus also the ICP values in the model of cellular brain edema.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Reference36 articles.
1. BARZÓ P, MARMAROU A, FATOUROS P, HAYASAKI K, CORWIN F: Contribution of vasogenic and cellular edema to traumatic brain swelling measured by diffusion-weighted imaging. J Neurosurg 87: 900-907, 1997.
2. BECKER DP, MILLER JD, WARD JD, GREENBERG RP, YOUNG HF, SAKALAS R: The outcome from severe head injury with early diagnosis and intensive management. J Neurosurg 47: 491-502, 1977.
3. BRACKEN MB, SHEPARD MJ, HOLFORD TR: Administration of methylprednisolone for 24 or 48 hours or tirilizad mesylate for 48 hours in the treatment of acute spinal cord injury. JAMA 277: 1597-1604, 1997.
4. BRAIN TRAUMA FOUNDATION: Guidelines for the management of severe traumatic brain injury. 3rd Edition. J Neurotrauma 24 (Suppl 1): 2007, 106 p.
5. BULLOCK R, ZAUNER A, TSUJI O: Excitatory amino acid release after severe human head trauma: effect of intracranial pressure and cerebral perfusion pressure changes. In: Intracranial Pressure IX. NAGAI H, KAMIYA K, ISHII S (eds), Springer, Tokyo, 1994, pp 264-267.
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