Abstract
Background: Hypertension and osteoporosis are worldwide diseases with high prevalence; the study was done to estimate the correlation between hypertension and bone turnover in a sample of Iraqi postmenopausal women with hypertension and obesity. Materials and Methods: A cross-sectional study was done on 99 hypertensive obese postmenopausal Iraqi women (65 hypertensive obese and 34 normotensive non obese). The serum calcium (Ca), phosphorus (Pi), and alka line phosphatase (ALP) levels were measured as a represen tative of bone markers. Results: The results demonstrated that serum alkaline phosphatase is significantly elevated in the case group compared to the controls. No significant changes were observed in the levels of Ca and Pi in the patient group, while a significant increase in alkaline phos phatase was observed. Conclusions: The study shows that the changes in the bone markers in the patient group are important risk factors and contribute to osteoporosis, and it declares the effect of hy pertension on bone turnover markers in Iraqi postmenopausal women with hypertension and obesity.
Reference29 articles.
1. Kotsis V, Stabouli S, Papakatsika S, et al. Mecha nisms of obesity-induced hypertension. Hypertens Res. 2010; 33:386-93.
2. Henning RJ. Obesity and obesity-induced inflam matory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity. Am J Cardiovasc Dis. 2021;11:504.
3. Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Car diology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014; 129: S1–S45.
4. Öksüz M, Göbel P. Obesity, Hypertension, and Kidney Dysfunction: Mechanical Links. Curr Nutr Food Sci. 2023; 19:282–90.
5. Phillips CL, O’Driscoll DM. Hypertension and ob structive sleep apnea. Nat Sci Sleep. 2013;43–52.