The Impact of Childhood Obesity on Inflammation, Innate Immune Cell Frequency, and Metabolic MicroRNA Expression

Author:

Carolan Eirin123,Hogan Andrew E.12,Corrigan Michelle1,Gaotswe Gadintshware1,O'Connell Jean14,Foley Niamh5,O'Neill Luke A.5,Cody Declan3,O'Shea Donal14

Affiliation:

1. Obesity Immunology Group (E.C., A.E.H., M.C., G.G., J.O., D.O.), Education and Research Centre, St Vincent's University Hospital, University College Dublin, Dublin 4, Ireland

2. National Children's Research Centre (E.C., A.E.H.), Dublin 12, Ireland

3. Department of Diabetes and Endocrinology (E.C., D.C.), Our Lady's Children's Hospital Crumlin, Dublin 12, Ireland

4. Department of Endocrinology (J.O., D.O.), St Columcille's Hospital, Loughlinstown, Dublin, Ireland

5. Trinity Biomedical Sciences Institute (N.F., L.A.O.), School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference20 articles.

1. Inflammation and metabolic disorders;Hotamisligil;Nature,2006

2. Multiple markers of inflammation and weight status: cross-sectional analyses throughout childhood;Skinner;Pediatrics,2010

3. Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome;Valle;Diabetes Metab,2005

4. Elevated serum IL-6, IL-8, MCP-1, CRP, and IFN-γ levels in 10- to 11-year-old boys with increased BMI;Utsal;Horm Res Paediatr,2012

5. Obese Mexican American children have elevated MCP-1, TNF-α, monocyte concentration, and dyslipidemia;Breslin;Pediatrics,2012

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