Discovery of a Novel Superpotent and Selective Melanocortin-4 Receptor Antagonist (HS024): Evaluation in Vitro and in Vivo**This work was supported by grants from the Swedish Medical Research Council (04X-05957), the Swedish Society for Medical Research, and the Estonian Science Foundation (Grant 3267); the Ants ja Maria Silvere ning Sigfried Panti Mälestusstipendium Foundation (to A.K.); and the Swedish Institute (to I.M.).

Author:

Kask Ants1,Mutulis Felikss23,Muceniece Ruta43,Pähkla Rein1,Mutule Ilze23,Wikberg Jarl E. S.3,Rägo Lembit1,Schiöth Helgi B.3

Affiliation:

1. Department of Pharmacology, University of Tartu (A.K., R.P., L.R.), Ulikooli 18, 50090 Tartu, Estonia;

2. the Department of Medicinal Chemistry (F.M., I.M.) Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia;

3. the Department of Pharmaceutical Pharmacology, Uppsala University (F.M., R.M., I.M., J.E.S.W., H.B.S.), 751 24 Uppsala, Sweden

4. the Laboratory of Pharmacology (R.M.), Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia;

Publisher

The Endocrine Society

Subject

Endocrinology

Reference49 articles.

1. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA.;Chhajlani;FEBS Lett,1992

2. The cloning of a family of genes that encode the melanocortin receptors.;Mountjoy;Science,1992

3. Molecular cloning of a novel melanocortin receptor.;Gantz;J Biol Chem,1993

4. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor.;Gantz;J Biol Chem,1993

5. Molecular cloning of a novel human melanocortin receptor.;Chhajlani;Biochem Biophys Res Commun,1993

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