Inhibition by Insulin of Glucocorticoid-Induced Gene Transcription: Involvement of the Ligand-Binding Domain of the Glucocorticoid Receptor and Independence from the Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Pathways

Author:

Pierreux Christophe E.1,Ursø Birgitte2,De Meyts Pierre2,Rousseau Guy G.1,Lemaigre Frédéric P.1

Affiliation:

1. Hormone and Metabolic Research Unit (C.E.P., G.G.R., F.P.L.) Louvain University Medical School Christian de Duve Institute of Cellular Pathology (ICP) B-1200 Brussels, Belgium

2. Department of Molecular Signaling (B.U., P.D.M.) Hagedorn Research Institute DK-2820 Gentofte, Denmark

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference55 articles.

1. Regulation of gene expression by insulin.;O’Brien;Biochem J,1991

2. Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver.;Lemaigre;Biochem J,1994

3. Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states.;Argaud;Diabetes,1996

4. Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription.;O’Brien;Science,1990

5. The cyclic adenosine 3′,5′-monophosphate- and the glucocorticoid dependent enhancers are targets for insulin repression of tyrosine aminotransferase gene transcription.;Ganss;Mol Endocrinol,1994

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