EJE Prize 2023: genes on steroids—genomic control of hepatic metabolism by the glucocorticoid receptor

Author:

Quagliarini Fabiana1ORCID,Makris Konstantinos1ORCID,Friano Marika E12ORCID,Uhlenhaut Nina Henriette12ORCID

Affiliation:

1. Institute for Diabetes and Endocrinology (IDE), Helmholtz Munich , Ingolstaedter Landstr. 1, 85764 Neuherberg , Germany

2. Metabolic Programming, TUM School of Life Sciences & ZIEL Institute for Food and Health , Gregor-Mendel-Str. 2, 85354 Freising , Germany

Abstract

AbstractGlucocorticoids are essential hormones produced by the adrenal cortex with prominent circadian rhythmicity and in times of stress. Glucocorticoids maintain liver homeostasis through coordinated activities that control the major pathways of energy metabolism. Glucocorticoids activate the glucocorticoid receptor (GR), a nuclear hormone receptor that regulates the transcription of hundreds of genes in response to ligand. This review aims to provide a comprehensive overview of glucocorticoid receptor signaling impact on glucose, amino acid, and lipid metabolism in the liver. We integrate fundamental and current findings elucidating key GR-regulated pathways from a physiologic, biochemical, and molecular point-of-view. Here, we focus on the transcriptional regulation of well-characterized hepatic GR target genes, and on those GR co-factors that coordinate nutritional and hormonal signals.

Funder

German Research Foundation

Publisher

Oxford University Press (OUP)

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism

Reference263 articles.

1. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions;Sapolsky;Endocr Rev.,2000

2. Mechanisms involved in the side effects of glucocorticoids;Schäcke;Pharmacol Ther.,2002

3. Therapeutic mechanisms of glucocorticoids;Vandewalle;Trends Endocrinol Metabol,2018

4. Glucocorticoid hormones are both a major circadian signal and major stress signal: how this shared signal contributes to a dynamic relationship between the circadian and stress systems;Spencer;Front Neuroendocrinol.,2018

5. Circadian rhythms and the HPA axis: a systems view;Androulakis;WIREs Mech Dis,2021

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