BRAFV600E Mutation Is Associated with Preferential Sensitivity to Mitogen-Activated Protein Kinase Kinase Inhibition in Thyroid Cancer Cell Lines

Author:

Leboeuf Rebecca1,Baumgartner Jacqueline E.1,Benezra Miriam1,Malaguarnera Roberta1,Solit David21,Pratilas Christine A.3,Rosen Neal41,Knauf Jeffrey A.1,Fagin James A.21

Affiliation:

1. Departments of Medicine (R.L., J.E.B., M.B., R.M., D.S., N.R., J.A.K., J.A.F.), Memorial Sloan Kettering Cancer Center, New York, New York 10021

2. Department of Human Oncology and Pathogenesis Programs (D.S., J.A.F.), Memorial Sloan Kettering Cancer Center, New York, New York 10021

3. Department of Pediatrics (C.A.P.), Memorial Sloan Kettering Cancer Center, New York, New York 10021

4. Department of Molecular Pharmacology (N.R.), Memorial Sloan Kettering Cancer Center, New York, New York 10021

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference32 articles.

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2. TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas.;Greco;Oncogene,1992

3. Prevalence of Ras mutations in thyroid neoplasia.;Esapa;Clin Endocrinol (Oxf),1999

4. Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations.;Zhu;Am J Clin Pathol,2003

5. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.;Kimura;Cancer Res,2003

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