Dabrafenib Versus Dabrafenib + Trametinib in BRAF-Mutated Radioactive Iodine Refractory Differentiated Thyroid Cancer: Results of a Randomized, Phase 2, Open-Label Multicenter Trial

Author:

Busaidy Naifa L.1,Konda Bhavana2,Wei Lai3,Wirth Lori J.4ORCID,Devine Catherine5,Daniels Gregory A.6,DeSouza Jonas A.7,Poi Ming8,Seligson Nathan D.9,Cabanillas Maria E.1,Sipos Jennifer A.10,Ringel Matthew D.10,Eisfeld Ann-Kathrin11,Timmers Cynthia12,Shah Manisha H.2

Affiliation:

1. Division of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

2. Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

3. Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

4. Division of Hematology and Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.

5. Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

6. Division of Hematology and Oncology, University of California San Diego Moores Cancer Center, La Jolla, California, USA.

7. Division of Medical Oncology, The University of Chicago, Chicago, Illinois, USA.

8. Department of Pharmacology, The Ohio State University, Columbus, Ohio, USA.

9. Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, USA.

10. Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University and The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

11. Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

12. Translational Sciences Discovery Lab, Incyte Corporation, Wilmington, DE, USA.

Publisher

Mary Ann Liebert Inc

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

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