Small, Dense Lipoprotein Particles and Reduced Paraoxonase-1 in Patients with the Metabolic Syndrome

Author:

Garin Marie-Claude Blatter1,Kalix Barbara1,Morabia Alfredo2,James Richard W.1

Affiliation:

1. Clinical Diabetes Unit (M.-C.B.G., B.K., R.W.J.), 1211 Geneva 4, Switzerland

2. Department of Endocrinology, Diabetes, and Nutrition, and Department of Clinical Epidemiology (A.M.), University Hospital, 1211 Geneva 4, Switzerland

Abstract

Abstract The presence of the metabolic syndrome (World Health Organization definition) and its association with lipoprotein abnormalities suggestive of greater susceptibility to oxidative stress have been analyzed in patients with angiographically defined coronary artery disease. The odds ratio for the presence of the metabolic syndrome was significantly higher in coronary artery disease-positive patients (P < 0.001). The metabolic syndrome was also associated with more severe coronary disease (P < 0.01). Patients with the metabolic syndrome had significantly decreased low-density lipoprotein-cholesterol/apolipoprotein B and high-density lipoprotein-cholesterol/apolipoprotein AI ratios, indicative of the presence of small, dense lipoprotein particles. The syndrome was also associated with reduced concentrations and activities of the antioxidant enzyme, paraoxonase-1. The metabolic syndrome is characterized by smaller, denser lipoprotein particles that increase their susceptibility to oxidative modifications and diminished serum paraoxonase-1, which is a major determinant of the antioxidant capacity of high-density lipoproteins. These may be contributory factors to the increased presence and severity of coronary disease in such patients.

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference36 articles.

1. Studien ueber das hypertonie-hyperglykämie-hyperurikämiesyndrom.;Kylin;Zentralblatt Innere Med,1923

2. Essential hyperlipaemia, obesity and diabetes.;Avogaro;Diabetologia,1965

3. The metabolic syndrome and vascular disease;Anwar;In: Johnstone MT, Veves A, eds. Diabetes and cardiovascular disease. Totowa, NJ: Humana Press;,2001

4. Banting Lecture 1988. Role of insulin resistance in human disease.;Reaven;Diabetes,1988

5. Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome.;Ferrannini;Diabetologia,1991

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3