GSK-3β Function in Bone Regulates Skeletal Development, Whole-Body Metabolism, and Male Life Span

Author:

Gillespie J. R.12,Bush J. R.12,Bell G. I.13,Aubrey L. A.12,Dupuis H.12,Ferron M.45,Kream B.6,DiMattia G.7,Patel S.8,Woodgett J. R.8,Karsenty G.4,Hess D. A.13,Beier F.2

Affiliation:

1. Department of Physiology and Pharmacology (J.R.G., J.R.B., G.I.B., L.A.A., H.D., D.A.H., F.L.B.), University of Western Ontario, London, Ontario, Canada

2. Children's Health Research Institute (J.R.G., J.R.B., L.A.A., H.D., F.B.), London, Ontario, Canada

3. Robarts Research Institute (G.I.B., D.A.H.), London, Ontario, Canada

4. Department of Genetics and Development (M.F., G.K.), Columbia University, New York, New York

5. Institut de recherches cliniques de Montréal (M.F.), Montréal, Canada H2W 1R7 and Institut de recherches cliniques de Montréal (M.R.), Montréal, Canada H2W 1R7

6. Department of Medicine (B.K.), University of Connecticut Health Center, Farmington, Connecticut 06030

7. Cancer Research Laboratory Program (G.D.), Lawson Health Research Institute, Departments of Biochemistry and Oncology, University of Western Ontario, London, Ontario, Canada

8. Samuel Lunenfeld Research Institute/Mt Sinai Hospital (S.P., J.R.W,), Toronto, Ontario, Canada

Publisher

The Endocrine Society

Subject

Endocrinology

Reference68 articles.

1. Endochondral ossification: how cartilage is converted into bone in the developing skeleton;Mackie;Int J Biochem Cell Biol,2008

2. Bone development;Olsen;Annu Rev Cell Dev Biol,2000

3. Developmental regulation of the growth plate;Kronenberg;Nature,2003

4. Molecular mechanisms of endochondral bone development;Provot;Biochem Biophys Res Commun,2005

5. Cell-cycle control and the cartilage growth plate;Beier;J Cell Physiol,2005

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