Substitution of Serine for Proline in the Active Center of Type 2 Iodothyronine Deiodinase Substantially Alters Its in Vitro Biochemical Properties with Dithiothreitol But Not Its Function in Intact Cells-Reference-Cited by-同舟云学术

Substitution of Serine for Proline in the Active Center of Type 2 Iodothyronine Deiodinase Substantially Alters Its in Vitro Biochemical Properties with Dithiothreitol But Not Its Function in Intact Cells

Published:2010-02-01 Issue:2 Volume:151 Page:821-829
ISSN:0013-7227
Container-title:Endocrinology
language:en
Short-container-title:

Author:

Goemann Iuri Martin¹,Gereben Balázs²,Harney John W.³,Zhu Bo³,Maia Ana Luiza¹,Larsen P. Reed³

Affiliation:

1. Thyroid Section (I.M.G., A.L.M.), Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS-90035-903, Brazil;

2. Laboratory of Endocrine Neurobiology Institute of Experimental Medicine (B.G.), Hungarian Academy of Sciences, Budapest H-1083, Hungary;

3. Thyroid Section (J.W.H., B.Z., P.R.L.), Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115

Publisher

The Endocrine Society

Subject

Endocrinology

Link

http://academic.oup.com/endo/article-pdf/151/2/821/10724227/endo0821.pdf

Reference35 articles.

1. Cellular and structural biology of the deiodinases.;Bianco;Thyroid,2005

2. Observations on the factors that control the generation of triiodothyronine from thyroxine in rat liver and the nature of the defect induced by fasting.;Balsam;J Clin Invest,1979

3. Thioredoxin stimulates enzymatic outer ring monodeiodination of reverse triiodothronine.;Goswami;Endocrinology,1987

4. The cDNA for the type I iodothyronine 5′-deiodinase encodes an enzyme manifesting both high Km and low Km activity. Evidence that rat liver and kidney contain a single enzyme which converts thyroxine to 3,5,3′-triiodothyronine.;Sharifi;J Biol Chem,1992

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