1. Department of Pathophysiology and Therapeutics (H.T., C.S.), Hokkaido University Faculty of Pharmaceutical Sciences, Sapporo 060-0812, Japan
2. Departments of Gastroenterology and Hematology (H.T., S.M., T.K., T.O., M.A.), Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
3. Department of Gastroenterology (S.M.), Tomakomai City General Hospital, Tomakomai 053-8567, Japan
4. Tsumura Research Laboratories (T.H., C.S., K.T.), Tsumura and Co., Ibaraki 300-1192, Japan
5. Department of Medical Information (T.O.), Hokkaido Information University, Ebetsu 069-8585, Japan
6. Otolaryngology-Head and Neck Surgery (N.O.), Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan