Tyr612 and Tyr632 in Human Insulin Receptor Substrate-1 Are Important for Full Activation of Insulin-Stimulated Phosphatidylinositol 3-Kinase Activity and Translocation of GLUT4 in Adipose Cells*

Author:

Esposito Diana L.1,Li Yunhua1,Cama Alessandro1,Quon Michael J.1

Affiliation:

1. Cardiology Branch, National Heart, Lung, and Blood Institute,National Institutes of Health, Bethesda, Maryland 20892;and Department of Oncology and Neurosciences, University G.D’Annunzio(D.L.E.,A.C.), Chieti 66013, Italy

Publisher

The Endocrine Society

Subject

Endocrinology

Reference48 articles.

1. Insulin signalling: metabolic pathways and mechanisms for specificity.;Nystrom;Cell Signal,1999

2. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action.;White;Recent Prog Horm Res,1998

3. Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells.;Quon;J Biol Chem,1994

4. Insulin receptor substrate-2 (IRS-2) can mediate the action of insulin to stimulate translocation of GLUT4 to the cell surface in rat adipose cells.;Zhou;J Biol Chem,1997

5. Action of insulin receptor substrate-3 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells.;Zhou;Mol Endocrinol,1999

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