Structural and functional features of the myocardium in residents of the industrial region of the Far North under the exposure to nickel and arsenic

Author:

Nosov Alexander E.1ORCID,Ustinova Olga Yu.1ORCID

Affiliation:

1. Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Abstract

The study of the role of chemicals of industrial origin in the development of cardiovascular pathology determines the relevance of this study. The purpose of the work is to study the features of cardiac structural and functional disorders in residents of the industrial region of the Far North under the exposure of nickel and arsenic. Materials and methods. The study included one hundred fifty eight women living in the industrial center of the Far North with the location of large metallurgical enterprises (observation group) and 65 women living in similar climatic and geographical conditions, but without the location of industrial enterprises (comparison group). An echocardiographic study was carried out with the measurement of structural and doppler parameters of the heart on an expert-class ultrasonic scanner “Vivid q”. Results. In the observation group the values of myocardial performance indices (MPI) values for mitral annulus (0.55 ± 0.09 vs. 0.48 ± 0.07, p=0.005) and tricuspid annulus (0.57 ± 0.10 vs. 0.48 ± 0.06, p=0.001) were higher than in the comparison group. A gain in the concentration of nickel in the blood is associated with an increase in isovolumic relaxation time (IVRT) of the mitral atrioventricular ring (p=0.0001) and systolic pressure in the pulmonary artery (p=0.00002). An increase in the concentration of arsenic in the blood is associated with an increase in the filling pressure of the left ventricle (E/Em) and end diastolic diameter of the left ventricle (EDD LV) (p=0.0001), the diameters of the right ventricle (RV) and right atrium (RA) (p=0.0001), and rate of late diastolic filling of the RV and MPI of the tricuspid atrio-ventricular ring (p=0.0001). Limitations. This study did not include middle aged and elderly women, and also did not include male patients and did not include the population of other territories except the Far North. Conclusion. The revealed changes in echocardiographic parameters indicate subclinical dysfunctions of the myocardium of the left and right ventricles, affecting both systolic and diastolic function in residents of the industrial city of the Far North, living under the influence of nickel and arsenic.

Publisher

Federal Scientific Center for Hygiene F.F.Erisman

Subject

Public Health, Environmental and Occupational Health,Health Policy

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3