Naujagimių ir kūdikių smegenų ląastelių apoptozė ir perioperacinis periodas: ar yra ryšys?

Abstract

In these latter decades neurotoxicity of general anaesthetics has been demonstrated in neonatal animal models. These data raised a concern about the safety of neonatal and paediatric anaesthesia. However, prospective epidemiological studies in humans are still ongoing. Biological markers, which could be associated with anaesthesia and outcome would be helpful in timely decisions regarding clinical practice in newborns and infants. To date, some brain specific proteins have been studies in various brain damage scenarios in neonates, children and adults. The purpose of the present paper is to describe current knowledge, based on experimental and clinical data, on the influence of anaesthetics on the developing brain and the applicability of certain biomarkers in cases of cerebral cell damage.