SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF CERTAIN 1,2,4-TRIAZOLE DERIVATIVES

Abstract

A new class of 1,2,4-triazole derivatives namely 3-(3,4-substituted-phenyl)-4-(4-fluoro-phenyl)-5-methyl-4H-1,2,4-triazoles (6a-6h) were synthesized. The structure of each novel compound was elucidated on the basis of elemental analysis, IR and 1H NMR spectral data. The pharmacological properties of 1,2,4-triazoles were enhanced by introducing alkyl, alkoxy and halogen substituents. The minimum inhibitory concentration was evaluated by broth dilution method. As predicted and as evidenced in the literature, the halogen substituted compounds were found to be better antimicrobial agents.