Affiliation:
1. Department of Pathology St. Jude Children's Research Hospital Memphis Tennessee USA
2. Department of Oncology Novant Health Presbyterian Medical Center Charlotte North Carolina USA
3. Department of Hematopathology MD Anderson Cancer Center Houston Texas USA
Abstract
AbstractHerein, we present a rare case of acute myeloid leukemia (AML) with CBFA2T3‐rearrangement and the expression of megakaryocytic and lymphoid markers, highlighting the need for a high suspicion index in differential diagnosis and applying adequate workup to avoid misdiagnosing this entity.CBFA2T3::GLIS2‐positive AML is primarily found in infants with non‐down syndrome acute megakaryoblastic leukemia (non‐DSAMKL). Flow cytometry immunophenotyping plays an important role in recognizing the unique immunophenotype of bright CD56 expression with dim/negative expression of HLA‐DR, CD38, and CD45 termed the RAM immunophenotype in this entity. Still, CBFA2T3::GLIS2‐positive acute leukemia with T/megakaryocytic markers could be misdiagnosed as T‐lymphoblastic leukemia/lymphoma, early T‐cell precursor acute lymphoblastic leukemia/lymphoma, NK lymphoblastic leukemia, AML with minimal differentiation, or AML with myelodysplasia‐related changes.
Subject
General Earth and Planetary Sciences