High‐resolution mass spectrometry‐based methodology for the identification of the metabolites of pterostilbene produced by rat, dog and human hepatocytes

Author:

Jiang Lingyan1,Yin Renlong2,Zheng Qiaofei3,He Chunyong4,Chang Huichao5ORCID

Affiliation:

1. Department of Pharmacy Taizhou Central Hospital (Taizhou University Hospital) Taizhou Zhejiang Province China

2. Department of Rehabilitation Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University Linhai Zhejiang Province China

3. Department of Clinical Laboratory Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University Linhai Zhejiang Province China

4. School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai China

5. Department of Pharmacy Zhejiang Hospital Hangzhou China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference20 articles.

1. Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)‐induced colon tumorigenesis via activation of the NF‐E2‐related factor 2 (Nrf2)‐mediated antioxidant signaling pathway;Chiou Y. S.;Journal of Agriculture and Food Chemistry,2011

2. Pterostilbene is equally potent as resveratrol in inhibiting 12‐O‐tetradecanoylphorbol‐13‐acetate activated NFkappaB, AP‐1, COX‐2, and iNOS in mouse epidermis;Cichocki M.;Molecular Nutrition & Food Research,2008

3. Identification of the metabolites of gigantol in rat urine by ultra‐performance liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry;Fan Y. M.;Biomedical Chromatography,2014

4. Food and Drug Administration. (2020).Guidance for industry: Safety testing of drug metabolites. Available at:https://www.fda.gov/media/72279/download

5. Properties of resveratrol: In vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans;Gambini J.;Oxidative Medicine and Cellular Longevity,2015

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