Design and analysis of a 3-arm noninferiority trial with a prespecified margin for the hazard ratio

Author:

Hida Eisuke1ORCID,Tango Toshiro2

Affiliation:

1. Department of Biostatistics and Data Science; Osaka University Graduate School of Medicine; Osaka Japan

2. Center for Medical Statistics; Tokyo Japan

Funder

MEXT KAKENHI

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology,Statistics and Probability

Reference36 articles.

1. Statistical principles for clinical trials. ICH harmonised tripartite guideline 1998 https://doi.www.ich. org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E9/Step4/E9_Guideline.pdf

2. Choice of control group and related issues in clinical trials. ICH harmonised tripartite guideline 2000 https://doi.www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E10/Step4/E10_Guideline.pdf

3. Guideline on the choice of the noninferiority margin (Doc. Ref. EMEA/CPMP/EWP/2158/99). European medicines agency 2005 https://doi.www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003636.pdf

4. Non-inferiority clinical trials to establish effectiveness. Food and drug administration 2016 https://doi.www.fda.gov/downloads/Drugs/Guidances/UCM202140.pdf

5. Testing Statistical Hypotheses of Equivalence and Noninferiority

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