Genetic and clonal dissection of osteosarcoma progression and lung metastasis

Author:

Xu Huaiyuan12,Zhu Xiaojun1,Bao Hua3ORCID,Wh Shek Tony4,Huang Zongwen5,Wang Yongqian1,Wu Xue3,Wu Yong6,Chang Zhili6,Wu Shuyu6,Tang Qinglian12,Zhang Huizhong7,Han Anjia8,Mc Cheung Kenneth9,Zou Changye1,Yau Raymond9,Ho Wai-Yip9,Huang Gang1,Batalha Sellma10,Lu Jinchang1,Song Guohui12,Kang Yao1,Shao Yang W.311,Lam Ying Lee9,Shen Jingnan1,Wang Jin12

Affiliation:

1. Department of Musculoskeletal Oncology; the First Affiliated Hospital of Sun Yat-Sen University; Guangzhou Guangdong China

2. Department of Musculoskeletal Oncology; Sun Yat-Sen University Cancer Center; Guangzhou Guangdong China

3. Translational Medicine Research Institute, Geneseeq Technology Inc.; Toronto Ontario Canada

4. Department of Pathology; University of Hong Kong, Queen Mary Hospital; Hong Kong China

5. Department of Orthopaedics; the Fifth Affiliated Hospital of Sun Yat-Sen University; Zhuhai China

6. Nanjing Geneseeq Technology Inc.; Nanjing Jiangsu China

7. Department of Pathology; Sun Yat-Sen University Cancer Center; Guangzhou China

8. Department of Pathology; the first Affiliated Hospital, Sun Yat-Sen University; Guangzhou China

9. Department of Orthopaedics and Traumatology; University of Hong Kong, Queen Mary Hospital; Hong Kong China

10. Department of Anatomic Pathology; Centro Hospitalar Conde de Sao Januario; Macau China

11. School of Public Health; Nanjing Medical University; Nanjing Jiangsu China

Funder

National Natural Science Foundation of China

Guangzhou Science and Technology Program key projects

Sun Yat-Sen University Clinical Research 5010 Program

The PhD program foundation of the Ministry of Education of China

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference36 articles.

1. The epidemiology of osteosarcoma;Ottaviani;Cancer Treat Res,2009

2. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma;Perry;Proc Natl Acad Sci USA,2014

3. Recent advances in osteosarcoma;Botter;Curr Opin Pharmacol,2014

4. Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency;Kovac;Nat Commun,2015

5. Whole exome sequencing of a single osteosarcoma case-integrative analysis with whole transcriptome RNA-seq data;Reimann;Hum Genomics,2014

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