Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency-Reference-Cited by-同舟云学术

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

Published:2015-12 Issue:1 Volume:6 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Kovac Michal,Blattmann Claudia,Ribi Sebastian,Smida Jan,Mueller Nikola S.,Engert Florian,Castro-Giner Francesc^ORCID,Weischenfeldt Joachim,Kovacova Monika,Krieg Andreas,Andreou Dimosthenis^ORCID,Tunn Per-Ulf,Dürr Hans Roland,Rechl Hans,Schaser Klaus-Dieter,Melcher Ingo,Burdach Stefan,Kulozik Andreas,Specht Katja,Heinimann Karl,Fulda Simone,Bielack Stefan,Jundt Gernot,Tomlinson Ian,Korbel Jan O.^ORCID,Nathrath Michaela,Baumhoer Daniel

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms9940.pdf

Reference39 articles.

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2. Chen, X. et al. Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. Cell Rep. 7, 104–112 (2014).

3. Perry, J. A. et al. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc. Natl Acad. Sci. USA 111, E5564–E5573 (2014).

4. Joseph, C. G. et al. Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas. Genes Chromosomes Cancer 53, 15–24 (2014).

5. Martin, J. W. et al. Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma. PLoS ONE 9, e95843 (2014).

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