Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet-transplantation enhances immediate post-transplant islet graft function but not long-term normoglycemia

Author:

Smink Alexandra M.1,Li Shiri2,Swart Daniël H.1,Hertsig Don T.3,de Haan Bart J.1,Kamps Jan A. A. M.1,Schwab Leendert3,van Apeldoorn Aart A.4,de Koning Eelco5,Faas Marijke M.16,Lakey Jonathan R. T.27,de Vos Paul1

Affiliation:

1. Department of Pathology and Medical Biology; University Medical Center Groningen, University of Groningen; Groningen The Netherlands

2. Department of Surgery; University of California Irvine; Orange

3. Polyganics; Groningen The Netherlands

4. Department of Developmental BioEngineering, Faculty of Science and Technology; University of Twente; Enschede The Netherlands

5. Department of Nephrology; Leiden University Medical Center; Leiden The Netherlands

6. Department of Obstetrics and Gynaecology; University Medical Center Groningen, University of Groningen; Groningen The Netherlands

7. Department of Biomedical Engineering; University of California Irvine; Irvine

Funder

Diabetes Cell Therapy Initiative (DCTI) (FES 2009 program, Dutch ministry of welfare and sports, and the Dutch diabetes research foundation)

JDRF short-term fellowship for discovery consortia grant (March 2015)

JDRF research grant (May 2016)

Publisher

Wiley

Subject

Metals and Alloys,Biomedical Engineering,Biomaterials,Ceramics and Composites

Reference51 articles.

1. Beta-cell transplantation in type 1 diabetic patients: A work in progress to cure;Gillard;Verh K Acad Geneeskd Belg,2010

2. Advances in pancreas transplantation;Dholakia;J R Soc Med,2016

3. Achieving and maintaining insulin independence in human islet transplant recipients;Hering;Transplantation,2005

4. Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience;Froud;Am J Transplant,2005

5. Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site;Carlsson;Diabetes,2001

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