A validated method for the quantification of IOX‐2, a potent prolyl hydroxylase inhibitor in equine urine and plasma using liquid chromatography–high‐resolution mass spectrometry-Reference-Cited by-同舟云学术

A validated method for the quantification of IOX‐2, a potent prolyl hydroxylase inhibitor in equine urine and plasma using liquid chromatography–high‐resolution mass spectrometry

Published:2021-02-06 Issue:6 Volume:13 Page:1178-1190
ISSN:1942-7603
Container-title:Drug Testing and Analysis
language:en
Short-container-title:Drug Test Anal

Author:

Mikhail Ezra¹^ORCID,Siccardi Erik²,Bawazir Ali¹,Rajesh Ambika¹,Prathyush Seetharani¹,Al Wazani Duaa Mohammad Kamal¹,Sabeek Muhammed¹,John Thomas¹

Affiliation:

1. Veterinary Sports and Research Centre, Wadi Al Safa Dubai UAE

2. Al Nasr‐2 Equine Clinic Dubai UAE

Publisher

Wiley

Subject

Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/dta.3010

Reference18 articles.

1. Federation for Equestrian Sports (FEI).2020 Equine Prohibited Substances List. (n.d.) Available at:https://inside.fei.org/sites/default/files/2020%20Prohibited%20Substances%20List_0.pdf

2. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

3. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

4. HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

5. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

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