Pharmacokinetics and tissue distribution study of clevidipine and its primary metabolite H152/81 in rats

Author:

Wang Yan12,Zhao Lanting1,Li Tengfei1,Yang Wen1,Li Qian1,Sun Luning3,Ding Li1ORCID

Affiliation:

1. Department of Pharmaceutical Analysis; China Pharmaceutical University; Nanjing China

2. College of Pharmacy and Chemistry; Dali University; Dali China

3. Research Division of Clinical Pharmacology; the First Affiliated Hospital with Nanjing Medical University; Nanjing China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference27 articles.

1. Clevidipine butyrate injectable emulsion;Cada;Hospital Pharmacy,2008

2. Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood;Cao;Bioanalysis,2015

3. A 15 years study of the causes of death among elderly hypertensive patients in a hospital-based sample of China;Cui;Archives of Gerontology and Geriatrics,2012

4. Clevidipine - A review of its use in the management of acute hypertension;Deeks;American Journal of Cardiovasc Drugs,2009

5. Pharmacokinetics of new calcium channel antagonist clevidipine in the rat, rabbit, and dog and pharmacokinetic/pharmacodynamic relationship in anesthetized dogs;Ericsson;Drug Metabolism and Disposition: The Biological Fate of Chemicals,1999

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