A Physiologically‐Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP‐1 and GIP and the DPP4 Inhibitor Sitagliptin
Author:
Affiliation:
1. Clinical Pharmacy Department Saarland University Saarbrücken Germany
2. Clinical Pharmacometrics Department Bayer AG Leverkusen Germany
3. esqLABS GmbH Saterland Germany
Funder
Ministry of Education
Publisher
Wiley
Subject
Pharmacology (medical),Modeling and Simulation
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12520
Reference49 articles.
1. On the Physiology of GIP and GLP-1
2. Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides
3. Significance of circulatory DPP4 activity in metabolic diseases
4. The Physiology of Glucagon-like Peptide 1
5. Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1(7–36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides
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