CYP3A4/5 mediates the metabolic detoxification of humantenmine, a highly toxic alkaloid from Gelsemium elegans Benth.-Reference-Cited by-同舟云学术

CYP3A4/5 mediates the metabolic detoxification of humantenmine, a highly toxic alkaloid from Gelsemium elegans Benth.

Published:2019-05-22 Issue:9 Volume:39 Page:1283-1292
ISSN:0260-437X
Container-title:Journal of Applied Toxicology
language:en
Short-container-title:J Appl Toxicol

Author:

Sun Rongjin¹²,Chen Minghao¹,Hu Yanxian³,Lan Yao¹,Gan Lili¹,You Guoquan¹,Yue Min⁴,Wang Hongmei⁵,Xia Bijun¹,Zhao Jie¹,Tang Lan¹,Cai Zeng¹,Liu Zhongqiu¹⁶,Ye Ling¹^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical SciencesSouthern Medical University Guangzhou China

2. School of Pharmaceutical SciencesHubei University of Medicine Shiyan Hubei China

3. Center For Certification And EvaluationGuangdong Food And Drug Administration Guangzhou China

4. Department of Laboratory Animal CenterSouthern Medical University Guangzhou China

5. Department of Radiation Oncology, Nanfang HospitalSouthern Medical University Guangzhou China

6. International Institute for Translational Chinese MedicineGuangzhou University of Chinese Medicine Guangzhou Guangdong Province China

Funder

Science and Technology Planning Project of Guangdong Province

Natural Science Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Wiley

Subject

Toxicology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jat.3813

Reference39 articles.

1. Fluvoxamine is a potent inhibitor of cytochrome P4501A2

2. Development of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains

3. Potential Beneficial Metabolic Interactions Between Tamoxifen and Isoflavones via Cytochrome P450-mediated Pathways in Female Rat Liver Microsomes

4. The genus Gelsemium: An update

5. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

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