CD59 ‐deficient bone marrow erythroid cells from rats treated with procarbazine and propyl‐nitrosourea have mutations in the Pig‐a gene-Reference-Cited by-同舟云学术

CD59 ‐deficient bone marrow erythroid cells from rats treated with procarbazine and propyl‐nitrosourea have mutations in the Pig‐a gene

Published:2020-08-18 Issue:8 Volume:61 Page:797-806
ISSN:0893-6692
Container-title:Environmental and Molecular Mutagenesis
language:en
Short-container-title:Environ Mol Mutagen

Author:

Revollo Javier R.¹,Dad Azra¹,Pearce Mason G.¹,Mittelstaedt Roberta A.¹,Casildo Andrea²,Lapidus Rena G.²,Robison Timothy W.³,Dobrovolsky Vasily N.¹

Affiliation:

1. Division of Genetic and Molecular Toxicology, National Center for Toxicological Research US Food and Drug Administration Jefferson Arkansas USA

2. Greenbaum Cancer Center University of Maryland School of Medicine Baltimore Maryland USA

3. Division of Pulmonary, Allergy and Critical Care Products, Center for Drug Evaluation and Research US Food and Drug Administration Silver Spring Maryland USA

Funder

U.S. Food and Drug Administration

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Genetics (clinical),Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.22402

Reference41 articles.

1. Evidence that the number of hematopoietic stem cells per animal is conserved in mammals

2. Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals

3. Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter ofPig-agene Mutation: Support from anin vitroassay based on L5178Y/Tk+/−cells and the CD90.2 antigen

4. Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene.

5. PIG-A mutations in paroxysmal nocturnal hemoglobinuria and in normal hematopoiesis

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1. Mutational signatures in T‐lymphocytes of rats treated with N ‐propyl‐ N ‐nitrosourea and procarbazine;Environmental and Molecular Mutagenesis;2021-06-30

2. Pig‐a gene mutations in bone marrow granulocytes of procarbazine‐treated F344 rats;Environmental and Molecular Mutagenesis;2021-03-13

3. Recommendations for conducting the rodent erythrocyte Pig‐a assay: A report from the HESI GTTC Pig‐a Workgroup;Environmental and Molecular Mutagenesis;2021-03

4. Molecular analysis of GPI-anchor biosynthesis pathway genes in rat strains used for the Pig-a gene mutation assay;Mutation Research/Genetic Toxicology and Environmental Mutagenesis;2020-10