Affiliation:
1. Pharmaceutical Development Biogen 115 Broadway Cambridge MA 02142 USA
2. Medicinal Chemistry Biogen 115 Broadway Cambridge MA 02142 USA
Abstract
AbstractSince the discovery of urea inclusion compounds (UICs) in 1940, the handedness of this chiral helical system has not been established experimentally. Here three UIC systems containing only light atoms were studied. The optical rotations were first measured, and the absolute structures of the enantiomorphic domains of three UICs were determined by single crystal X‐ray diffraction (SCXRD). The correlation between the optical rotation and the absolute configuration of the UICs was finally established, showcasing the power of absolute structure determination by SCXRD, which is essential in structural chemistry and pharmaceutical research.
Subject
General Chemistry,Catalysis,Organic Chemistry
Cited by
4 articles.
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