Affiliation:
1. Department of Natural Sciences Mid Sweden University Holmgatan 10 85179 Sundsvall Sweden
2. Department of Materials and Environmental Chemistry Arrhenius Laboratory Stockholm University 10 691 Stockholm Sweden
Abstract
AbstractFunctionalized triose‐, furanose and chromane‐derivatives were synthesized by the titled reactions. The sugar‐assisted kinetic resolution/C−C bond‐forming cascade processes generate a functionalized sugar derivative with a quaternary stereocenter in a highly enantioselective fashion (up to >99 % ee) by using a simple combination of metal and chiral amine co‐catalysts. Notably, the interplay between the chiral sugar substrate and the chiral amino acid derivative allowed for the construction of a functionalized sugar product with high enantioselectivity (up to 99 %) also when using a combination of racemic amine catalyst (0 % ee) and metal catalyst.
Subject
General Chemistry,Catalysis,Organic Chemistry