Acenaphthoimidazolylidene‐Ligated Palladacycle Enabled Suzuki–Miyaura Cross‐Coupling Employing Equimolar Organoboron for Tri‐Ortho‐Substituted Bi(hetero)aryls and Teraryls

Abstract

AbstractThe Pd‐catalyzed Suzuki‐Miyaura cross‐couplings (SMRs) are utilized as the most practical method to construct C−C bond, especial for biaryls. However, a major disadvantage of current protocols is the requirement of excess organoboron coupling partner (1.5–3.0 equiv.). Herein, a novel palladacyclic 1,3‐bis(2,6‐diisopropylphenyl)acenaphthoimidazol‐2‐ylidene (AnIPr) precatalyst possessing a chiral oxazoline was designed, which enabled a general protocol towards bulky tri‐ortho‐substituted biaryls, ternaphthalenes and diarylanthracenes via the Pd‐catalyzed SMR employing equimolar organoborons and aryl bromides. A remarkable scope of substrates with various functional groups and heterocycles were well compatible with an adaptability to synthesize useful ligands.